http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100320772-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B55-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-36 |
| filingDate | 1999-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100320772-B1 |
| titleOfInvention | Process for Preparation of (S)-Benzoxazine Derivatives and Process for Racemization of (R)-Benzoxazine Derivatives |
| abstract | (RS) -3-alkyl-7,8-dihalogeno-2,3-dahydro-4H [1,4] benzoxazine racemic compound and (S) -2- (6-methoxynaphthyl- 2-yl) propionyl chloride is reacted by mixing in an organic solvent in a molar ratio of 1: 0.5 to 0.6; Aqueous acid solution containing N-[(2S) -2- (6-methoxynaphthyl-2-yl) propionyl]-(3S) -3- Separating the organic layer material containing alkyl-7,8-dihalogeno-2,3-dihydro-4H [1,4] benzoxazine; The organic layer material was washed, dried, treated with activated carbon, filtered, and distilled under reduced pressure, followed by filtration by adding a nonpolar solvent under an ice container to obtain N-[(2S) -2- (6-methoxynaphthyl-2-yl]-( 3S) -3-alkyl-7,8-dihalogeno-2,3-dihydro-4H [1,4] benzoxazine I compound and compound II were separated; an acid was added to the benzoxazine I compound to hydrolyze it This gives (S) -3-alkyl-7,8-dihalogeno-2,3-dihydro-4H [1,4] benzoxazine derivative (S) -1 compound. An acid was added to the compound to hydrolyze it, and the above unreacted product containing a large amount of (R) -1 compound was added thereto, and 0.1 to 1 molar ratio of acid was added to the mixed solution, and 5 to 20 at a temperature of 100 to 150 ° C. A racemization reaction was performed for a time to prepare a (RS) -1 racemate compound. |
| priorityDate | 1998-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.