| abstract |
The present invention relates to pyrrolidine or piperidine derivatives of the general formula (1) or (2) for the treatment of diseases caused by overactivation of N-methyl-D-aspatate (N-methyl-D-aspatate) receptor subtypes , Or a pharmaceutically acceptable addition salt thereof, and a pharmaceutically acceptable carrier.n n n n n n n n n n n n n n n n n Wheren n n R 1 and R 2 independently of one another are hydrogen, lower alkoxy, hydroxy, halogen, -CONH 2 or -C (O) O-lower alkyl, or together are -OCH 2 O-,n n n R 3 and R 4 are independently of each other hydrogen, lower alkoxy, benzyloxy, halogen, hydroxy, -CONH 2 or -SCH 3 , or together are -OCH 2 O-,n n n R 5 is hydrogen or lower alkyl,n n n X and Y are independently from each other -CH (OH)-,-(CH 2 ) n- , -C (O)-or -CH (lower alkoxy)-,n n n m, n and p are 1 or 2. |