http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100318693-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C251-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C251-86 |
| filingDate | 1998-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100318693-B1 |
| titleOfInvention | Improved methods of preparing 4-cyano-4-(substituted indazole)cyclohexanecarboxylic acids useful as pde4 inhibitors |
| abstract | The present invention is directed to (a) treating a compound of Formula 1a with an alcohol comprising a compound of Formula 1ba and an acid comprising a compound of Formula 1bb to give an acidic condition that Forming a salt and (b) hydrolyzing the compound of formula 1c to provide a compound of formula 1n n n n n n n n n n n n n n n n n n n R a -OHn n n n n n n HXn n n n n n n n n n n n Wheren n n R a is essentially hydrogen; (C 1 -C 6 ) alkyl; And phenyl and (C 1 -C 3 ) alkyl-phenyl, wherein the phenyl group is essentially — (C 1 -C 4 ) alkyl, —O (C 1 -C 3 ) alkyl, Br and Cl Optionally substituted with one or two substituents selected from the group consisting ofn n n HX is essentially hydrobromic acid; Hydrochloric acid; Sulfuric acid; Sulfonic acid; And an acid selected from the group consisting essentially of aliphatic and aromatic sulfonic acids selected from the group consisting of methanesulfonic acid, trifluoromethanesulfonic acid, benzenesulfonic acid, benzylsulfonic acid, p-toluenesulfonic acid and camphorsulfonic acid. |
| priorityDate | 1997-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 114.