| abstract |
Compounds of formula (I) include arthritis, cancer, tissue ulceration, muscle degeneration, restenosis, periodontal disease, epidermal bleb, scleritis, and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, Useful for the treatment of diseases selected from the group consisting of septic stroke and other diseases associated with TNF production. In addition, the compounds of the present invention may be combined with standard non-steroidal anti-inflammatory drugs (hereinafter NSAID'S) and analgesics and also cytotoxic drugs in the treatment of cancers such as adriamycin, daunomycin, cis-platinum, etoposide, taxol , Taxotere, and alkaloids, for example, can be used in combination with vincristine.n n n <Formula I> |