http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100312454-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8adec6c65f65acc63fceb85c3d3b0d9 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12R2001-465 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P1-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-22 |
| filingDate | 1999-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2001-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de81f6dd69fd1a3bd3fe8f464811d0b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfe312c9b4a251c7749145fffdadb84a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c7f970d8e3ed068e4ba85412fc047bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9857631f2636fcd7dc6e0cfe9a94eac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f11a19090d3175edd5dd7b6a6c6cca5b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea9f8d21231f91cf3678717fcf057613 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b2f8cb39f945fe0f16100b5966caffe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d941863eb076f30ef27545dc6414527 |
| publicationDate | 2001-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100312454-B1 |
| titleOfInvention | Streptomyces sp. Producing Tautomycetin and Immunosuppressant Comprising Tautomycetin as Active Ingredient |
| abstract | The present invention is a Streptomyces genus microorganism that produces totomycintin useful as an immunosuppressive agent and antimicrobial agent, a method for producing totomycintin from the electric microorganism and the production of interleukin-2 (Te-cell activation end product) Immunosuppressive agent containing tomycetin as an active ingredient, which has the effect of inhibiting, inhibiting cell surface expression of CD69, inhibiting cell surface expression of interleukin-2 receptor, and inhibiting rejection according to tissue or organ transplantation, and its inhibitor It relates to a composite composition. The present inventors confirm that the material produced from a microorganism derived from soil and having antimicrobial activity and immunosuppressive activity is totomycetin, and after analyzing the microbial properties of the electric microorganism, it is identified as a novel Streptomyces spp. Totomycetin was prepared from the culture solution. In addition, the present inventors have confirmed that totomycetin inhibits mouse mixed lymphocyte response, and using the T-cell transformed with a recombinant gene fragment designed to know the expression level of the interleukin-2 gene, In the expression of the interleukin-2 gene efficiently and in rat transplantation experiments, it was confirmed that tomycintin significantly increased the survival rate of cardiac receptors by effectively maintaining the activity of the transplanted heart. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101489994-B1 |
| priorityDate | 1998-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 310.