| abstract |
The present invention describes a novel cholecystokinin antagonist of formula (I), which is useful as a therapeutic agent for obesity, excess gastric acid in the digestive tract, gastrin dependent tumors or a psychotic agent and has excellent bioavailability. In addition the compounds are anti-anxiety agents and anti-ulcer agents. It is useful to prevent response to chronic treatment discontinuation associated with the use of nicotine, diazepam, alcohol, cocaine, coffee or opioids. The compounds of the present invention are also useful for treating and / or preventing panic attacks. Pharmaceutical compositions and methods of making these compounds are also described. An important feature of the present invention is the absolute oral bioavailability of the compound. |