| abstract |
The present invention relates to a diarylbenzopyran derivative represented by the following general formula (I) and a pharmaceutically acceptable salt thereof, and a cyclooxygenase-2 inhibitor composition containing these in an effective amount. It is about.n n n (Ⅰ)n n n In the above formula,n n n X is O, NR 5 or S (O) n,n n n (Wherein n is 0, 1 or 2,n n n R 5 is hydrogen or a lower alkyl group having 1 to 6 carbon atoms.)n n n Y is O or S,n n n R 1 and R 2 are the same as or different from each other, and are hydrogen, halogen, lower alkyl having 1 to 6 carbon atoms, alkoxy, hydroxy or nitro group,n n n R 3 is hydrogen, halogen, lower alkyl having 1 to 6 carbon atoms, nitro, S (O) nR 6 or NR 7 R 8 ,n n n Wherein n is as defined in X above,n n n R 6 is hydrogen, a lower alkyl group having 1 to 6 carbon atoms, or NR 9 R 10 ,n n n (Wherein R 9 and R 10 are hydrogen or a lower alkyl group having 1 to 6 carbon atoms)n n n R 7 and R 8 are hydrogen or a lower alkyl group having 1 to 6 carbon atoms.)n n n R 4 is benzo [b] thienyl, naphthyl, phenylethynyl, phenylethenyl or a substituent having the following structures.n n n n n n n n Wherein R 11 to 15 are the same as or different from each other, and are hydrogen, halogen, lower alkyl having 1 to 6 carbon atoms, trifluoromethyl, alkoxy, hydroxy, nitro, S (O) nR 6 , trifluoromethoxy, acetyl Or formyl group.n n n (Where n or R 6 Is X and R 3 As defined in.)n n n or n n n In the above formula, R 16 to 18 are the same as or different from each other, and are hydrogen, halogen or lower alkyl group having 1 to 6 carbon atoms.n n n (Where n or R 6 Is X and R 3 As defined in.) |