| abstract |
A stable and effective multivalent vaccine composition consisting of hepatitis B surface antigen (HBsAg) is described, wherein the HBsAg component is stable for one week at 37 ° C. and is highly immune, for example, when the vaccine is administered to a child. The composition typically consists of a vaccine suitable for use in pediatric vaccines absorbed in aluminum phosphate HBsAg and other antigens, in particular aluminum phosphate or aluminum hydroxide. Vaccine preparation methods and the use of aluminum phosphate to stabilize HBsAg in multivalent vaccine combinations are also described. |