| abstract |
The method for producing sulfamide according to the present invention comprises the step of reacting an oxycarbonylsulfamide compound and an alcohol in the presence of an azodicarboxylic acid derivative and a trivalent phosphorus compound.n n n In one embodiment of the present invention, the sulfamide is represented by the following general formula (I), the alcohol is represented by the following general formula (II), and the oxycarbonyl sulfamide compound is represented by the following structural formula (III) Method for producing a sulfamide, characterized in that.n n n R 3 NHSO 2 NR 1 R 2 (I)n n n [Wherein R 1 and R 2 are each independently selected from hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, aryl, heterocyclic group and alkyl group substituted with these heterocyclic groups; ; R 3 is a group selected from alkyl, alkenyl, alkynyl, aralkyl, heterocyclic group, alkyl substituted with heterocyclic group and pyrrolidinyl methyl (the heterocyclic groups described above are pyranosyl, furanosyl, pipepe Lidinyl, pyrrolidinyl, azetidinone ring, cefem ring, penem ring and carbapenem ring);n n n R 3 OH (II)n n n Provided that R 3 is as defined above;n n n R 4 OOC-NHSO 2 NR 1 R 2 (III)n n n Wherein R 1 and R 2 are as defined above and R 4 is a carboxy protecting group. |