| abstract |
The present invention relates to compounds of formula (I) below, which are antagonists of gastrin and CCK-B receptor.n n n n n n n n Wherein R 1 is phenyl, C 3-7 cycloalkyl, C 7-11 bridged cycloalkyl or C 1-6 alkyl, wherein the alkyl group is hydroxy, phenyl, C 1-6 alkoxycarbonyl, C 3-7 cyclo Alkyl or a C 7-11 bridged cycloalkyl group, and R 2 is substituted or unsubstituted phenyl, wherein the substituent is one or two halo, C 1-4 alkyl, nitro, cyano, trifluoro Chloromethyl, trifluoromethoxy, C 1-4 alkylthio or (CH 2 ) nR 4 where R 4 is hydroxy, C 1-4 alkoxy, CO 2 R 5 or NR 6 R 7 , and R 5 is hydrogen Or C 1-4 alkyl, R 6 and R 7 may independently be hydrogen or C 1-4 alkyl, n is 0 or l), and R 3 is optionally selected from 1 or 2 halogen atoms Substituted phenyl, R 8 is hydrogen or a halogen atom, m is 0, 1 or 2; |