| abstract |
The present invention relates to pharmaceutically useful protoberberine salt derivatives and protoberberine derivatives and salts thereof, and more particularly, to the protoberberine salt derivatives represented by the following formula (1) and the protoberberine derivatives represented by the following formula (2) It relates to salts thereof. The compounds according to the invention exhibit excellent mortality and / or growth inhibitory effects on fungi.n n n Formula 1n n n n n n n n Formula 2n n n n n n n n In Formulas 1 and 2, R 1 , R 2 and R 4 are the same as or different from each other, an alkoxy group having 1 to 5 carbon atoms, R 3 is a hydrogen atom or an alkyl group having 1 to 10 carbon atoms, R 5 is a hydrogen atom or the following formula The group represented by 11, A − is an inorganic acid ion, organic acid ion or halide:n n n Formula 11n n n n n n n n Wherein Z 1 , Z 2 , Z 3 , Z 4 , Z 5 are the same or different from each other hydrogen, halogen, alkyl group having 1 to 5 carbon atoms, trifluoromethyl, phenyl, substituted phenyl, nitro, 1 to 4 carbon atoms Individual alkoxy, trifluoromethoxy, hydroxy, phenoxy, vinyl, methoxycarboxyl groups. |