| abstract |
The present invention relates to 4-hydroxy-piperidine derivatives of formula (1) and pharmaceutically acceptable addition salts thereof.n n n Formula 1n n n n n n n n In Chemical Formula 1,n n n X is -O-, -NH, -CH 2- , -CH =, -CHOH-, -CO-, -S-, -SO- or -SO 2- ,n n n R 1 to R 4 are independently of each other hydrogen, hydroxy, lower alkyl-sulfonylamino, 1- or 2-imidazolyl or acetamido,n n n R 5 to R 8 are independently of each other hydrogen, hydroxy, lower alkyl, halogen, lower alkoxy, trifluoromethyl or trifluoromethyloxy,n n n a and b may be double bonds provided that "b" cannot be a double bond, provided that "a" is a double bond,n n n n is 0 to 2,n n n m is 1 to 3,n n n p is 0 or 1.n n n Compounds of the present invention are NMDA (N-methyl-D-aspartate) -receptor subtype selective blockers, which are based on the development of the CNS, which includes the formation and function of learning and memory. It can be used in mediating processes. |