| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5ab8d5e4558668a6dd1124fec4302976 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14 |
| filingDate |
1997-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2000-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee22edeb0371851cca8f4ffb7d4d9c09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c823c6392a6341b49ac566f55b36e7f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21751d984933b7a43653186fd5f7a495
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8a3f46dda0b61a2a04d30cf2492466a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51bcba107e7d6680c34e61749481d922
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29756c2bd93127a215e613bdabd6f7d0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1d3718765f51d885315078ade1e082b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2206bae6b3c05dd9607dc054a606f34d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce7abe608543c5cab940c7d4ea454e08 |
| publicationDate |
2000-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-100250241-B1 |
| titleOfInvention |
Manufacturing method of paclitaxel |
| abstract |
The present invention relates to (a) an oxazolidine of formula (4) by coupling an oxazolidine dimer derivative of formula (2) or a salt thereof to a 7-trihaloacetyl-baccatin III of formula (3) in the presence of a condensing agent in a solvent: Preparing a side chain-containing taxane dimer; (b) ring-opening an oxazolidine ring in the presence of an acid in a solvent and reacting with benzoyl chloride in the presence of a base in the case where R is t-butoxycarbonyl to prepare 7-trihaloacetyl paclitaxel of Formula 5 ; (c) a method of preparing paclitaxel of formula (I) characterized by removing trihaloacetyl in 7-position with ammonia or a salt of ammonia and a weak acid in a solvent.n n n [Formula 2]n n n n n n n n [Formula 3]n n n n n n n n [Formula 4]n n n n n n n n [Formula 5]n n n n n n n n [Formula 1]n n n n n n n n In the above formulan n n R represents t-butoxycarbonyl or benzoyl,n n n R 1 represents trihaloacetyl. |
| priorityDate |
1997-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |