http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100248558-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e493dbb326bdb84242fbc9af833f128e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-30 |
| filingDate | 1992-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2000-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa542edc0575f82b53de82870859a9b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b16241b7228ab1f5cd842617bb0ad83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9ee2d59cb15e2b05f4afc58988620bd |
| publicationDate | 2000-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100248558-B1 |
| titleOfInvention | Substituted tetrahydroisoquinoline, preparation method thereof and pharmaceutical composition comprising the same |
| abstract | FIELD OF THE INVENTION The present invention relates to tetrahydroisoquinoline compounds of formula (I), pharmaceutically acceptable salts thereof and O-acylated derivatives thereof, wherein the anesthesia and psychosis (eg schizophrenia), Parkinson's disease, Lesh-Nian syndrome And lipophilic esters useful for the treatment of intensive deficiency or cognitive impairment or for the alleviation of drug dependent or delayed dyskinesia.n n n n n n n n Wheren n n R is H, halo, hydroxy, alkyl having 1 to 3 carbon atoms (optionally substituted by hydroxy), alkoxy having 1 to 3 carbon atoms, alkylthio having 1 to 3 carbon atoms, alkylsulfinyl having 1 to 3 carbon atoms Selected from 1 to 3 alkylsulfonyl, nitro, cyano, polyhaloalkyl of 1 to 3 carbon atoms (optionally substituted by one or more substituents selected from alkyl of 1 to 3 carbon atoms and alkoxy of 1 to 3 carbon atoms) Carbamoyl optionally alkylated by one or more or one or two alkyl groups of 1 to 3 carbon atoms,n n n R 2 is an aliphatic group having 1 to 3 carbon atoms optionally substituted by alkoxy or hydroxy having 1 to 3 carbon atoms,n n n E is an alkylene chain of 2 to 6 carbon atoms optionally substituted with 1 to 3 carbon atoms and at least one alkyl group,n n n G may be phenyl or the same or different, and is independently alkyl having 1 to 3 carbon atoms, alkoxy having 1 to 3 carbon atoms, halo, hydroxy, polyhaloalkyl having 1 to 3 carbon atoms, polyhalo having 1 to 3 carbon atoms. Alkoxy, cyano, alkylthio having 1 to 3 carbon atoms, alkylsulfinyl having 1 to 3 carbon atoms, alkylsulfonyl having 1 to 3 carbon atoms, (halo, alkyl having 1 to 3 carbon atoms and alkoxy having 1 to 3 carbon atoms Phenyl optionally substituted by one or more of the above substituents or a phenyl substituted by one or more substituents which are carbamoyl optionally alkylated by one or two alkyl groups of 1 to 3 carbon atoms, or a heterocyclic or aromatic carbocyclic ring fused Phenyl ring. |
| priorityDate | 1991-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 612.