| abstract |
The present invention relates to formula (I) wherein A 1 , A 2 and A 3 are independently carbon or nitrogen, and one of R 1 , R 3 , R 4 and R 6 (R 1 , R 3 or R 6 is lactam Is a known quinolone substituent, and one of R 1 , R 3 or R 6 is a lactam containing moiety], a protected form of the compound, salts, pharmaceutically acceptable salts, raw Provided is a process for preparing a hydrolyzable ester or solvate thereof, wherein the process comprises one or more organosilicon compounds of formula (II) [where A 1 , A 2 , A 3 , R 1 , R 3 , R 4 and R 6 is the same as above (one of R 1 , R 3 or R 6 may be a lactam containing moiety) and X is a leaving group], a compound in its protected form, a salt, pharmaceutical To an acceptable salt, biohydrolyzable ester or solvate thereof. Compounds prepared by the methods of the present invention may be useful as antimicrobials per se or used as intermediates for preparing other quinolone containing antimicrobials. |