abstract |
The present invention relates to compounds of formula (I) and pharmaceutically acceptable acid addition salts thereof.n n n [Formula 1]n n n n n n n n Wherein, X is -0-, -NH-, -CH 2 -, -C0 2 -, -C0NH-, -C0N ( lower alkyl) -, -S- or -S0 2 -, and, R 1 to R 4 Are independently of each other hydrogen, halogen, hydroxy, amino, nitro, lower-accyl-sulfonylamido, 1- or 2-imidazolyl, 1- (1,2,4-triazolyl) or acetamido , R 5 and R 6 are independently of each other hydrogen, lower alkyl, hydroxy, lower alkoxy or oxo, and R 7 to R 10 are independently of each other hydrogen, lower alkyl, halogen, trifluoromethyl or lower-alkoxy, n is 0 or 1;n n n Compounds of the invention are NMDA (N-methyl-D-aspartate) -receptor subtype specific blockers. |