| abstract |
In the present invention, Z is represented by the following Chemical Formula 2, 3, 4 or 5, wherein X is methylene, thio, -N (H)-or oxy; Y is a 5 or 6 member which can incorporate oxygen or a reducing agent. Completes an aromatic or partially saturated ring, T is methylene, -N (H)-, thio or oxy); Or Z is of the formula: wherein D may be saturated carbon, oxygen or thio; Or Z is of formula 7, wherein A completes a 7 to 9 membered monounsaturated single aza ring; R 1 , R 2 , R 3 , m, n, p and q are as defined herein. It relates to certain 4-aminoquinazolins of formula (1) and pharmaceutically acceptable salts and isomers thereof. Compounds of formula (1) are useful for the treatment of hyperproliferative diseases, in particular as anticancer agents.n n n [Formula 1]n n n n n n n n [Formula 2]n n n n n n n n [Formula 3]n n n n n n n n [Formula 4]n n n n n n n n [Formula 5]n n n n n n n n [Formula 6]n n n n n n n n [Formula 7] |