http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100216336-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71b3be70086419df7430dcf0abc1da93 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-51 |
| filingDate | 1991-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1999-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5bf96ff3084491a6310bea4f5328c267 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7a94b9538012f21a560c9575069320c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32586c568919bd09f4b9d6c3dca91c09 |
| publicationDate | 1999-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100216336-B1 |
| titleOfInvention | Method for preparing oral hepatitis B vaccine using viral vector |
| abstract | To develop the hepatitis B vaccine for oral use, a poliovirus with invasion pathway through the small intestine mucosa was used as a carrier. Attenuated poliovirus is a very safe virus that is currently used orally.n n n In order to induce immunity against the hepatitis B virus, a gene encoding the hepatitis B virus surface antigen must be inserted into the polio virus gene, but if a large amount of exogenous gene is inserted, the polio virus proliferation ability will be lost. The gene encoding the hepatitis B virus surface antigen should be substituted to the extent that it does not affect the proliferation of the virus.n n n In the present invention, a gene encoding the antigenic determinant site having the best immunogenicity among the surface antigens of the hepatitis B virus is synthesized using the above principle, and then replaced with the antigenic determinant site in the poliovirus gene region to generate a recombinant hepatitis-poliovirus. A vector was made and transfected into primate cells to make a recombinant virus, and the orally hepatitis B vaccine was prepared by mass culturing the propagated recombinant virus. |
| priorityDate | 1991-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.