| abstract |
The present invention relates to a compound of formula (I) and pharmaceutically acceptable acid addition salts or stereochemical isomers thereof for use as a medicament.n n n n n n n n Wherein R 1 and R 2 are each independently hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl, or R 1 and R 2 are pyrrolidinyl together with the nitrogen atom to which R 1 and R 2 are attached Can form a piperidinyl, morpholinyl, piperazinyl or 4-C 1-4 alkylpiperazinyl group; X is oxygen or sulfur; R 3 is hydrogen or C 1-6 alkyl; R 4 , R 5 and R 6 are each independently hydrogen, halo, C 1-6 alkyl, C 1-6 alkyloxy, nitro, trifluoromethyl, cyano, aminomethyl, carboxyl, C 1-4 alkyl Oxycarbonyl, C 1-4 alkylcarbonyl, aminocarbonyl or hydroxy; R 7 is hydrogen or halo; R 8 , R 9 and R 10 are each independently hydrogen, halo, C 1-6 alkyl, C 1-6 alkyloxy, nitro, hydroxy, trifluoromethoxy, 2,2,2-trifluoroethoxy , (Trifluoromethyl) carbonyl, aminocarbonyl, (cyclopropyl) carbonyl or radical C 1-6 alkyl- (C = Y)-, where = Y is = O, = N-OH, = N-OCH 3 , = N-NH 2 or = NN (CH 3 ) 2 ; Provided that (1) R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 9 and R 10 represent hydrogen, R 8 is 4-ethoxy and X represents 0, 1 is not n-propyl, (2) R 1 , R 2 , R 3 , R 6 , R 7 , R 8 , R 9 and R 10 represent hydrogen, and R 4 and R 5 represent 3,4-dimethy In the case of oxy, X is not sulfur.n n n The present invention also relates to novel compounds, pharmaceutical compositions containing said general formula (I) compounds, and methods of preparing said compositions. |