| abstract |
The novel pyrazine derivatives of the general formula (1) and salts thereof have an inhibitory effect on the superoxide radicals (O 2 − ) which are released from the macrophage of mormot by stimulation, and also in Masugi nephritis It has antiproteinuria activity.n n n n n n n n The pyrazine derivatives of (1) and salts thereof are various diseases caused by the above-mentioned superoxide radicals, for example, autoimmune diseases such as rheumatoid arthritis, arteriosclerosis, microesophageal heart disease, transient cerebral focal seizures, and liver failure. As well as useful drugs for preventing and treating renal failure, etc., it is a useful drug for preventing and treating nephritis in various clinical fields. |