http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-0158430-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_52a24331fe7882d8a0801155df05d542 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4746 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-82 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-82 |
| filingDate | 1994-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86390d2474c3e9674c52b468009601ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7146d3e920998120f1bfb3d0962a5aa8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3df32c462064e29cd32b43e73f065aa |
| publicationDate | 1998-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-0158430-B1 |
| titleOfInvention | Inhibition of Hepatitis B Virus Replication with p53 Protein |
| abstract | The present invention relates to a novel use of p53 protein as a replication inhibitor of hepatitis B virus, which inhibits the replication of hepatitis B virus by inhibiting the activity of the pregenomic / core promoter of hepatitis B virus. Wild type p53 inhibits the activity of the prigenome / core promoter, thereby inhibiting the replication of HBV. Inhibition of HBV replication by p53 in the present invention is the amount of surface antigen (HBsAg) and core protein (HBc / eAg) branched into cell culture medium; DNA amount of HBV determined by Southern blot analysis; The RNA amount of HBV determined by Northern blot analysis was confirmed. The p53 protein of the present invention or a functional equivalent thereof may be used for the prevention of acute and chronic hepatitis, cirrhosis and liver cancer caused by HBV. |
| priorityDate | 1994-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 213.