| abstract |
The present invention relates to a novel pyrimidine derivative represented by the following general formula (I) having excellent gastric acid secretion inhibitory effect, or a pharmaceutically acceptable salt thereof, and a preparation method thereof.n n n n n n n n Wherein A is 1-substituted-1,2,3,4-tetrahydroisoquinolin-2-yl of formula (II-1) or 7-substituted-4,5,6 of formula (II-2) , 7-tetrahydrothieno [2,3-c] pyridin-6-yl. And R 1 , R 2 , R 6 are hydrogen or C 1-3 alkyl, R 3 is hydrogen or halogen, R 4 , R 5 are the same or different from each other and are hydrogen, C 1-3 alkyl, or ring together To form cyclopentyl or cyclohexyl. |