http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-0141881-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b923f1231bcc22e6bde34dd04f21809 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-188 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1804 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1892 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J23-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-08 |
| filingDate | 1994-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ba52134f91c6b4d88c268409b3826f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bd2c1cf7647332cda5c9db396cd834a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b4b6615ae8ab4414519c36db7acb7b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c384eb57e06829f3c64c175fa1a2637 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ddfd3627946208705baa9787a2cdde03 |
| publicationDate | 1998-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-0141881-B1 |
| titleOfInvention | Stereoselective preparation method of (E) -enolthioether derivative |
| abstract | According to the present invention, the free secondary hydroxy group of L-threonine is protected with a trialkylsilyl group, followed by degradation of the protected L-threonine derivative (I) with ninhydrin (2R) -2- (trialkylsilyl Oxy) propanal (II), and stabilized phosphonate illide, phosphine oxide il obtained by treating organic phosphorus compounds such as dialkylphosphonates, diarylphosphine oxides and triarylphosphoniums with strong bases (E)-(3R) -3-t-butyldimethylsilyloxy-1-phenyl by owner-Wardsword-Amons (HWE) reaction of lead or phosphonium illide with aldehyde (II) obtained above Thio-1-butene, (E)-(3R) -3-t-butyldimethylsilyloxy-1- (p-methoxyphenylthio) -1-butene, (E)-(3R) -3-t- Butyldimethylsilyloxy-1- (p-chlorophenylthio) -1-butene and (E)-(3R) -3-t-butyldimethylsilyloxy-1- (p-methylphenylthio) -1-butene (E) -enolthioether derivative (IV) A method for selective production of material is provided.n n n Compared with the conventional production methods, the production cost can be lowered by obtaining the target compound (IV) through a short production process using L-threonine, which is a cheap α-amino acid, as a starting material, and compared with the conventional production methods (E ) -Enolthioether derivatives have the advantage that they can be prepared with high stereoselectivity. |
| priorityDate | 1994-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 156.