| abstract |
The present invention is a compound having a derivative of a pyrrolidine group substituted with an aminooxy group at the 7-position of the quinolone mother nucleus, and has a novel quinoline and naphthyridine carboxyl of formula (I) having excellent antibacterial action and broad antibacterial spectrum. Acid derivatives, pharmaceutically acceptable salts thereof, solvates thereof, and methods for their preparation.n n n n n n n n n n Wherein Q is CH, CF, C-Cl, CO-alkyl (C 1 -C 4 ), or N, R 1 is ethyl, cyclopropyl or phenyl substituted with one or more fluorine atoms, R 2 is Hydrogen, methyl, or amino, R 3 is hydrogen, hydroxy, C 1 -C 4 alkoxy, or NR 6 R 7 , wherein R 6 and R 7 are each independently hydrogen or C 1 -C 4 alkyl, or R 6 and R 7 may be linked together with the nitrogen atom to which they are attached to form a 4 to 8 membered ring which may optionally contain one or more additional heteroatoms selected from N, O or S). , n is 0 or 1, and R 4 and R 5 may each independently form hydrogen, C 1 -C 4 alkyl, or C 1 -C 4 alkenes in which two groups are connected together by a double bond to a nitrogen atom. |