http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-0133981-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1532cae5cef0d7b37d22500263519417 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10 |
| filingDate | 1994-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8cd4bdc6643eabf47d492c215a9bae6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61997e922adc7add345f3ee230632356 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ceea2116cc70244c24ebbeb50b4fa817 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df9a8da97e6fd12f7757621e6a4fffa9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b162462eefb3d27503a08d31286aa2c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1dcc9345989653d7711bcb8fecd7c85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3358cc524bb6cb87476de25c7cb5e882 |
| publicationDate | 1998-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-0133981-B1 |
| titleOfInvention | Novel Gamma-Aminobutylate Aminotransferase |
| abstract | The present invention relates to a novel gamma-aminobutyrate aminotransferase (EC 2.6.1.19.) Isolated from bovine brain. In the present invention, purified from bovine brains, GABA-T is a dimer of about 100,000 Daltons composed of the same two chains of monomers each having a molecular weight of about 50,000 Daltons, and 43% of the structure of GABA-T is α-helix (α- helix). In addition, as a result of examining specificity of several substrates, it was found that GABA-T performs an effective amino group transfer reaction on the amount of GABA in vivo. Thus, GABA-T was purified and biochemical and molecular biological studies of this enzyme were performed to compare the structure and amino acid sequence of GABA-T with porcine brain tissue or liver, and to explore the structure of the enzyme activity site. The present invention provides basic information on the development of inhibitors of GABA-T that can be raised to treat epilepsy. |
| priorityDate | 1994-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 372.