| abstract |
Nucleic acid with less cytotoxicity as a side effect and improved ability to suppress MEX3B gene expression, MEX3B gene expression suppressant containing the above nucleic acid, method for suppressing MEX3B gene expression, and preventive or therapeutic agent for diseases caused by MEX3B gene expression. To provide. A nucleic acid that is any of the following (1) to (3). (1) Oligonucleotide consisting of the nucleotide sequence shown in SEQ ID NO: 1 or 2 in the sequence listing (2) One or two bases are deleted, substituted and / in the nucleotide sequence shown in SEQ ID NO: 1 or 2 in the sequence listing. Alternatively, an antisense oligonucleotide consisting of an added base sequence and suppressing the expression of the MEX3B gene (3) An antisense oligonucleotide containing the base sequence shown in SEQ ID NO: 3 in the sequence listing and suppressing the expression of the MEX3B gene. |