| abstract |
An object of the present invention is to rapidly elute (S, E) -N- (1-((5- (2-((4-cyanophenyl) amino)) in a weakly acidic solution in order to prevent a decrease in bioavailability. ) -4- (propylamino) pyrimidin-5-yl) pent-4-in-1-yl) amino) -1-oxopropan-2-yl) -4- (dimethylamino) -N-methylbut-2- To provide a tablet containing a succinate of eneamide (Compound A). According to the present invention, (S, E) -N- (1-((5- (2-((4-cyanophenyl) amino) -4- (propylamino) pyrimidin-5-yl) pent-4- From the group consisting of succinates, sugars and sugar alcohols of in-1-yl) amino) -1-oxopropan-2-yl) -4- (dimethylamino) -N-methylbut-2-enamide (Compound A). Tablets containing at least one as well as crospovidone are provided. |