http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2020032152-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-067 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-067 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H9-04 |
| filingDate | 2019-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-WO2020032152-A1 |
| titleOfInvention | Stereoselective synthesis of 4'-substituted nucleoside derivatives |
| abstract | The current method for synthesizing a 4'-substituted nucleoside derivative includes a step of producing a stereoisomer, which causes problems such as a decrease in yield and a complicated purification step. Therefore, a simpler synthetic method that does not generate a stereoisomer is required. The present invention provides a method for synthesizing a 4'-substituted nucleoside intermediate represented by the formula (6), which comprises the following steps 1 to 3. Step 1: A step of obtaining a compound of formula (4) in which a substituent is stereoselectively introduced by causing a nucleophile to act on the compound of formula (3) using the compound of formula (3) as a starting material. Step 2: Hydrolyze the compound of formula (4) to obtain the compound of formula (5), and Step 3: Hold the compound of formula (5) under acidic conditions to obtain the compound represented by formula (6). Process [Chemical 3] In the above formula, R 1 represents a hydroxyl-protecting group, Me represents a methyl group, and X represents a substituent. |
| priorityDate | 2018-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 153.