| abstract |
An object of the present invention is a chemically modified siRNA in which polydeoxyadenylic acid is added to the 5'end of the sense strand, and when complexed with sizophyran, it has high resistance to RNase and effectively enhances RNAi activity. To provide the chemically modified siRNA shown. In a modified siRNA in which polydeoxyadenylic acid is added to the 5'end of the sense strand, the dinucleotide sequences of CA, UA, and UG in the base sequence of the sense strand, and the 8th and subsequent from the 5'end side of the antisense strand. The above-mentioned problems can be solved by subjecting the dinucleotide sequences of CA, UA, and UG in the base sequence of the above to specific chemical modifications. |