abstract |
An object of the present invention is to provide an antibody that can be expected to have an autoimmune disease therapeutic effect and an anticancer therapeutic effect by inhibiting the migration of lymphocytes by inhibiting the S1P transport of SPNS2. The present invention is a SPNS2-neutralizing antibody or a fragment thereof, or a derivative thereof, which specifically binds to SPNS2 of vertebrates and has an activity of inhibiting lymphocyte migration through inhibition of S1P transport. |