| abstract |
The present invention exhibits gastric solubility according to drug properties without causing premature elution and absorption even when an aqueous suspension type pharmaceutical preparation is orally administered, and particle growth and particle aggregation. Aqueous suspension type pharmaceutical preparation containing the following (1) to (4) and having a pH in the range of 2.5 to 5.5, which can suppress the above: (1) (3aR, 4S, 7R, 7aS) -2-{(1R, 2R) -2- [4- (1,2-benzoisothiazole-3-yl) piperazine-1-ylmethyl] cyclohexylmethyl} hexahydro -4,7-methano-2H-isoindole-1,3-dione, a pharmaceutically acceptable acid addition salt thereof or a mixture thereof, (2) One or more chlorides selected from inorganic chlorides or quaternary ammonium chlorides having 4 to 12 carbon atoms. (3) Dispersant and (4) Water are provided. |