| abstract |
Even when a poorly water-soluble active ingredient is used, a skin external preparation is provided that can enhance the permeability to the part of the epidermis below the stratum corneum and the dermis. . A water-soluble active ingredient and a solubilizer, wherein the solubilizer is at least one selected from the group consisting of a water-soluble polymer, a water-soluble saccharide, a water-soluble surfactant, and an aromatic carboxylic acid. A topical skin preparation. |