| abstract |
The present invention relates to an anti-RAMP2 antibody having a cAMP inhibitory effect and an HUVEC growth inhibitory effect, and provides an angiogenesis inhibitor containing the antibody as an active ingredient. Specifically, an antibody against receptor activity-regulating protein 2 (RAMP2) or an immunoreactive fragment thereof, which has an inhibitory effect on the growth of vascular endothelial cells in an in vitro proliferation test, or cAMP by animal cells by adding adrenomedulin. The present invention relates to an antibody having an action of suppressing production or an immunoreactive fragment thereof. |