abstract |
The anti-HSV monoclonal antibody or an antigen-binding fragment thereof is an anti-HSV gB monoclonal antibody or an antigen-binding fragment thereof that specifically binds to envelope glycoprotein B (gB) of herpes simplex virus (HSV), and is represented by SEQ ID NO:3. A heavy chain variable region comprising a heavy chain CDR1 having the amino acid sequence described, a heavy chain CDR2 having the amino acid sequence set forth in SEQ ID NO:4, and a heavy chain CDR3 having the amino acid sequence set forth in SEQ ID NO:5; A light chain CDR1 having the amino acid sequence described, a light chain CDR2 having the amino acid sequence set forth in SEQ ID NO:7, and a light chain variable region including the light chain CDR3 having the amino acid sequence set forth in SEQ ID NO:8. |