http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2018230712-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5076 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5064 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6863 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-15 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate | 2018-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-WO2018230712-A1 |
| titleOfInvention | Novel screening method for TGF-β inhibitor |
| abstract | The present invention provides a method for screening compounds effective for diseases in corneal endothelium. The method of the present invention comprises (a) bringing a candidate compound into contact with an immortalized cell of Fuchs's corneal endothelial dystrophy in the presence of transforming growth factor (TGF) -β, and the inhibitory activity of the candidate compound on the TGF-β is shown. Evaluation, selecting a compound having the inhibitory activity, (b) evaluating the toxicity of the compound selected in step (a) to the cells, and (c) selecting in step (a) The step of evaluating the inhibitory activity of the compound against the TGF-β, and (d) the step (b) of which the toxicity to the cells is evaluated to be low, and the step (c) of having the inhibitory activity against the TGF-β. Then, selecting the evaluated compound. By the method of the present invention, it is possible to screen a compound effective for a disease in corneal endothelium. |
| priorityDate | 2017-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 266.