| abstract |
The present invention provides a nucleic acid molecule that effectively suppresses the expression of a hepatitis B virus gene, and a pharmaceutical composition containing the nucleic acid molecule for suppressing the proliferation of hepatitis B virus, and treating hepatitis B, cirrhosis, and liver cancer. provide. Specifically, a nucleic acid molecule comprising the following nucleotide sequence (i) or (ii) as a hepatitis B virus gene expression suppressing sequence (i) a nucleotide sequence represented by SEQ ID NO: 2; A nucleotide sequence in which one or two bases are deleted, substituted, inserted, or added in the nucleotide sequence represented by SEQ ID NO: 2; or 90% or more identity with the nucleotide sequence represented by SEQ ID NO: 2 (Ii) a nucleotide sequence represented by SEQ ID NO: 1; A nucleotide sequence in which one or two bases have been deleted, substituted, inserted, or added to the nucleotide sequence represented by SEQ ID NO: 1; or 90% or more identity with the nucleotide sequence represented by SEQ ID NO: 1 A nucleotide sequence having the formula: |