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filingDate 2018-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2020-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-WO2018190313-A1
titleOfInvention Percutaneous absorption liquid containing memantine
abstract An object of the present invention is to provide an external preparation containing memantine, which has reduced skin irritation, has excellent skin permeability, and is suitable for continuous administration for a long period of time. The external preparation according to the present invention comprises, in addition to memantine or a salt thereof, 0.05 to 1.5% by weight of phosphatidylcholine, 35 to 55% by weight of propylene glycol, 18 to 30% by weight of glycerin, and 22 to 32% by weight. Percutaneous absorption type liquid containing water. When the content of water is less than 22% by weight, skin irritation may increase, and when it exceeds 32% by weight, skin permeability may decrease. When the content of glycerin is less than 18% by weight, skin irritation may increase, and when it exceeds 30% by weight, skin permeability may decrease.
priorityDate 2017-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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