| abstract |
INDUSTRIAL APPLICABILITY The present invention can be manufactured in a simple process, has a small column pressure loss even with a small particle size, and is suitable for use as a packing material for size exclusion chromatography for preparative purposes requiring large-scale processing. It is an object to provide a filler and a method for producing the filler. In the present invention, a step of polymerizing glycerin-1,3-dimethacrylate and glycidyl methacrylate in the presence of a polymerization initiator, a step of hydrophilizing porous particles comprising the obtained copolymer with a sugar alcohol, A packing step for size exclusion chromatography is obtained by a production step including a step of ring-opening the residual glycidyl group with a mineral acid. |