http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2018135027-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y501-03017 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-26 |
| filingDate | 2017-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-WO2018135027-A1 |
| titleOfInvention | Method for producing heparosan compound in which hexuronic acid residue is isomerized |
| abstract | The present invention provides a method for producing a heparosan compound in which the hexuronic acid residue is isomerized and a method for producing heparan sulfate, with improved C5-epimerization efficiency. Specifically, the present invention includes generating a heparosan compound in which a hexuronic acid residue is isomerized from a heparosan compound in the presence of a protein selected from the group consisting of (A) to (F) below. A method for producing a heparosan compound in which hexuronic acid residues are isomerized is provided: (A) a protein comprising the amino acid sequence of SEQ ID NO: 2; (B) a protein comprising an amino acid sequence having 90% or more homology with the amino acid sequence of SEQ ID NO: 2 and having D-glucuronyl C5-epimerase activity; (C) a protein having an amino acid sequence in which one or several amino acid residues are deleted, substituted, added or inserted in the amino acid sequence of SEQ ID NO: 2 and having D-glucuronyl C5-epimerase activity; (D) a protein comprising the amino acid sequence of SEQ ID NO: 5; (E) a protein comprising an amino acid sequence having 90% or more homology with the amino acid sequence of SEQ ID NO: 5 and having D-glucuronyl C5-epimerase activity; and (F) one or a number in the amino acid sequence of SEQ ID NO: 5 A protein comprising an amino acid sequence in which one amino acid residue is deleted, substituted, added or inserted, and having D-glucuronyl C5-epimerase activity. |
| priorityDate | 2017-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 261.