| abstract |
Provided is a method for easily and efficiently producing an optically active 4-carbamoyl-2,6-dimethylphenylalanine derivative useful as a pharmaceutical intermediate. 4-Carbamoyl-2,6-dimethylbenzyl alcohol is prepared by reacting 4-carbamoyl-2,6-dimethylbenzoic acid, carbamoyl chloride and base to produce the corresponding mixed acid anhydride and reducing it. Manufacturing. By using this compound, an optically active 4-carbamoyl-2,6-dimethylphenylalanine derivative can be produced simply and efficiently. |