abstract |
A compound represented by the general formula (I) (wherein all symbols are as described in the description), a salt thereof, a solvate thereof, an N-oxide thereof or a prodrug thereof is a potent FXIa inhibitor. It is a compound that has excellent oral absorption and blood kinetics, exhibits strong anticoagulant activity for a long time after oral administration, and has a difference between anticoagulant activity and CYP inhibitory activity. It can be a preventive and / or therapeutic agent for embolic diseases. |