| abstract |
PROBLEM TO BE SOLVED: To provide a bispecific antibody for preventing or treating an immunoinflammatory disease by acting on both human TLR2 and human TLR4 and inhibiting the immunoinflammatory action via human TLR2 and human TLR4. A heavy chain variable region of an anti-human TLR2 antibody consisting of an amino acid sequence of SEQ ID NO: 4 from amino acid Nos. 1 to 120, an anti-human TLR2 antibody light chain consisting of an amino acid sequence of SEQ ID No: 6 from amino acid Nos. 1 to 113 An anti-human TLR4 antibody consisting of a variable region of a heavy chain, an anti-human TLR4 antibody heavy chain consisting of an amino acid sequence of amino acid numbers 491 to 609 of SEQ ID NO: 4, and an amino acid sequence of amino acid numbers 625 to 732 of SEQ ID NO: 4 Bispecific antibodies against human TLR2 and human TLR4 were provided that contain light chain variable regions. [Selection figure] None |