| abstract |
The present invention provides an intermediate for producing an atropisomer of a pyrrole derivative having an excellent mineralocorticoid receptor antagonistic activity, a production method thereof, and a crystal thereof. An optically active amine having a cinchonane skeleton is used, the following general formula (I) [Chemical 1] [Wherein, R 1 represents a methyl group or a trifluoromethyl group, R 2 represents a hydrogen atom or a C1-C3 alkoxy group, and n represents an integer selected from 1 to 3. And a process for producing an atropisomer of a pyrrole derivative, and (S) -1- (2-hydroxyethyl) -4-methyl-N- [4- (methylsulfonyl) phenyl] Crystals of -5- [2- (trifluoromethyl) phenyl] -1H-pyrrole-3-carboxamide. |