| abstract |
Provision of a novel α-position halogen-substituted thiophene compound having a potent LPA receptor antagonistic activity and useful as a pharmaceutical, or a pharmacologically acceptable salt thereof General Formula (I): [Wherein, A is a phenyl ring, a thiophene ring, or an isothiazole ring; R 1 is the same or different and is a halogen atom or a C 1 -C 3 alkyl group; R 2 is a hydrogen atom; Or C 1 -C 6 alkyl group; p is an integer of 0 to 5; V is CR 3 (wherein R 3 is a hydrogen atom, an amino group, a nitro group, or a C 1 -C 3 alkoxy group) Or a nitrogen atom; X represents a halogen atom. Or a salt thereof. |