| abstract |
【Task】 An object of the present invention is to provide a novel pyruvate dehydrogenase inhibitor. [Solution] Pyruvate dehydrogenase inhibitor containing a compound represented by the general formula (I) as an active ingredient (wherein ring A has an aromaticity optionally substituted with 2 to 4 substituents) Represents a hydrogen ring, R 1 and R 4 are the same or different and each represents a hydrogen atom, a hydroxyl group, an optionally substituted C1-6 alkyl group or the like, and R 2 and R 3 are the same or different, atom, carboxyl group, optionally substituted C1~6 alkyl group, C6-10 aryl group, or, -C (= R 9) a group represented by -R 10), the pyruvate dehydrogenase kinase inhibitors A pharmaceutical composition for treating or preventing a disease or disorder associated with the onset or exacerbation of pyruvate dehydrogenase kinase, and a cosmetic composition. |