abstract |
The present invention provides a compound represented by the formula (I) {wherein X 1 is an oxygen atom, R 1 is a formula (IIA) (wherein R 5A is a halogen, R 6A Is a hydrogen atom etc.), or formula (IVA) (wherein Y 3A is a nitrogen atom etc., Y 4A is CH etc.), etc., and R 2 is a hydrogen atom, hydroxy, halogen or substituent R 3 has a nucleotide residue or a nucleoside residue represented by a hydrogen atom or the like, and the nucleotide residue or nucleoside residue passes through an oxygen atom at the 3-position. Provided is an oligonucleotide having an improved affinity for AGO2 that binds to an adjacent nucleotide residue. |