| abstract |
Formula (1): Xe-Pro / Ala / Hyp-Xa-Xb-Xc-Xd (wherein Xe is an amino acid residue having an isoelectric point of 5.9 to 6.3, and Pro / Ala / Hyp is , Pro, Ala or Hyp, Xa is an amino acid residue or deletion other than Hyp, Pro and Arg, Xb is Gly, Pro or deletion, Xc is Pro, Ala or deletion, Xd is an amino acid It is a DPP-4 inhibitor comprising a peptide represented by The inhibitor can be expected to have a blood glucose level lowering effect by enhancing the action of incretin, and can be used as a therapeutic agent for diabetes, and can also be used for treatment of skin diseases by acting on the immune system. |