http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2012133121-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1277 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1278 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-28 |
| filingDate | 2012-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-WO2012133121-A1 |
| titleOfInvention | Sustained sustained release liposome composition and production method thereof |
| abstract | The present invention relates to a water-miscible organic solution containing a total concentration of phospholipid and cholesterol of 100 to 200 w / v% in a water-miscible organic solvent, and a volume ratio of the first aqueous phase solution to volume 1. 3/1 to 12/1 to obtain an emulsion in which the total concentration of phospholipid and cholesterol in the mixed phase is 15 to 50 w / v%, and the emulsion is replaced with a second aqueous phase solution. Liposome composition in which an ion gradient is formed between the internal region aqueous phase of the liposome membrane composed of the first aqueous phase solution and the external region aqueous phase of the liposome membrane composed of the second aqueous phase solution in the obtained liposome composition The present invention provides a liposome composition capable of introducing a drug in a high encapsulated amount, and a liposome preparation suitable for subcutaneous administration and the like, having sustained sustained release while maintaining a clinically sufficient effective concentration. |
| priorityDate | 2011-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 119.