http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2012118136-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0054 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0032 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0093 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0069 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate | 2012-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-WO2012118136-A1 |
| titleOfInvention | Switching type fluorescent nanoparticle probe and fluorescent molecular imaging method using the same |
| abstract | Provided is a novel fluorescent nanoparticle probe for imaging having a switching function (a function in which a fluorescent dye is quenched in a blood component and emits fluorescence at a tumor or an inflammatory site to be imaged). A fluorescent nanoparticle probe comprising a molecular assembly comprising an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain, and a fluorescent dye encapsulated in the molecular assembly, comprising: (a) a hydrophilic block The chain contains a unit selected from a sarcosine unit and an alkylene oxide unit as a hydrophilic essential constituent unit, and (b) the hydrophobic block chain is a hydrophobic unit selected from the group consisting of an amino acid unit and a hydroxyl acid unit. It is included as an essential structural unit, and (c) the fluorescent dye is represented by the following formula (I): [Chemical 1] A fluorescent nanoparticle probe, which is a polylactic acid-binding cyanine compound comprising a fluorescent group represented by formula (1) and a polylactic acid group having 5 to 50 lactic acid units, wherein the fluorescent dye is included in a plurality of molecules per one molecular assembly. [Selection] Figure 1 |
| priorityDate | 2011-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 89.