| abstract |
A compound represented by the following general formula (I), which exhibits an ADAM17 inhibitory action, or a salt thereof, or a solvate thereof [wherein, X is a phenylene group; Y is a hydrogen atom or — (CH 2 ) m R 1 R 1 is —NR 5 COR 2 , —NR 5 SO 2 R 2 or —NR 3 R 4 ; R 2 is a C1-C6 alkyl group, an aryl group, or a C1-C6 alkoxy group; R 3 and R 4 are C1 ~C6 alkyl group or the like; R 5 is, like hydrogen atom or a C1~C6 alkyl group; m is 0 to 4 integer of: Z represents a hydrogen atom or a C1~C6 alkyl group. ]. |